Do NOT use Advair Diskus if:

• you are allergic to any ingredient in Advair Diskus or to milk proteins
• you are having an asthma attack (eg, sudden, severe onset or worsening of asthma symptoms such as chest tightness, cough, shortness of breath, wheezing)
• you are using another type of long-acting inhaled bronchodilator (eg, formoterol inhalation powder, salmeterol inhalation powder)
• you are taking an azole antifungal (eg, ketoconazole), certain HIV protease inhibitors (eg, ritonavir), a macrolide antibiotic (eg, clarithromycin), nefazodone, or telithromycin.

Contact your doctor or health care provider right away if any of these apply to you.

Some medical conditions may interact with Advair Diskus. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding
• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
• if you have allergies to medicines, foods, or other substances
• if you are taking a monoamine oxidase inhibitor (MAOI) (eg, phenelzine) or tricyclic antidepressant (eg, amitriptyline), or if you have taken either of these medicines within the last 14 days
• if you have high blood acid levels (eg, ketoacidosis) or a history of diabetes, glaucoma, or increased pressure in the eye, heart problems (eg, fast or irregular heartbeat, heart blood vessel problems), high blood pressure, nervous system problems, liver problems, low blood potassium levels, seizures, thyroid problems, or an adrenal gland tumor
• if you are having a COPD flare-up, have recently been to an emergency room for asthma, have a history of frequent hospitalizations for asthma, or have ever had a life-threatening asthma attack
• if you have a fungal, bacterial, or parasitic infection; a viral infection (eg, measles, chickenpox, shingles); herpes virus infection of the eye; tuberculosis (TB); a history of a positive TB skin test; or immune system problems; or if you have had a recent vaccination
• if you have weak bones (osteoporosis) or have risk factors for osteoporosis (eg, a family history of osteoporosis, tobacco use, long-term use of corticosteroids or certain seizure medicines, limited physical exercise, poor nutrition).

Some medicines may interact with Advair Diskus. Tell your health care provider if you are taking any other medicines, especially any of the following:

• Diuretics (eg, hydrochlorothiazide, furosemide) or long-acting inhaled bronchodilators (eg, salmeterol inhalation powder, formoterol inhalation powder) because the risk of low blood potassium or irregular heartbeat may be increased
• Beta-blockers (eg, propranolol) because they may decrease Advair Diskus's effectiveness
• Azole antifungals (eg, ketoconazole), catechol-O-methyltransferase (COMT) inhibitors (eg, entacapone), delavirdine, HIV protease inhibitors (eg, ritonavir), macrolide antibiotics (eg, clarithromycin), MAOIs (eg, phenelzine), nefazodone, short-acting beta-agonist bronchodilators (eg, albuterol), telithromycin, or tricyclic antidepressants (eg, amitriptyline) because they may increase the risk of Advair Diskus's side effects.

This may not be a complete list of all interactions that may occur. Ask your health care provider if Advair Diskus may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

Important safety information:

• Advair Diskus may cause dizziness. This effect may be worse if you take it with alcohol or certain medicines. Use Advair Diskus with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
• Advair Diskus will not stop an asthma attack once one has started. Be sure to carry a short-acting bronchodilator with you at all times to treat any breathing problems that may occur between doses of Advair Diskus (eg, severe or sudden onset of wheezing or shortness of breath). 
• If you have been regularly using a short-acting bronchodilator inhaler (eg, albuterol), talk with your doctor about how to use it with Advair Diskus. Short-acting bronchodilators are normally only used with Advair Diskus to treat breathing problems that may occur between doses.
• Talk with your doctor or pharmacist about all of your asthma medicines and how to use them. Do not start, stop, or change the dose of any asthma medicine unless your doctor tells you to.
• If your symptoms do not get better within 1 week or if they get worse after you start using Advair Diskus, check with your doctor.
• Tell your doctor or dentist that you take Advair Diskus before you receive any medical or dental care, emergency care, or surgery.
• Tell your doctor at once if you notice your short-acting bronchodilator inhaler does not work as well, if you need to use it more often (eg, more than 4 times a day for more than 2 days in a row, or 1 whole canister within 8 weeks' time), or if you have a decrease in your peak meter flow results.
• The risk of serious heart problems (eg, irregular heartbeat) may be greater if you use Advair Diskus in high doses. Do NOT use more than the recommended dose or use for longer than prescribed without checking with your doctor.
• Advair Diskus may sometimes cause severe breathing problems right after you use a dose. If this happens, use your short-acting bronchodilator inhaler. Seek medical care at once if your breathing does not improve after you use the short-acting bronchodilator. Tell your doctor about this reaction.
• Use caution if you switch from an oral steroid (eg, prednisone) to Advair Diskus. It may take several months for your body to make enough natural steroids to handle events that cause physical stress. Such events may include injury, surgery, infection, a sudden asthma attack, or severe fluid or electrolyte loss. These may be severe and sometimes fatal. Contact your doctor right away if any of these events occur. You may need to take an oral steroid (eg, prednisone) again. 
• If you have not had chickenpox, shingles, or measles, avoid contact with anyone who does. Contact your doctor at once if you have contact with anyone who has these infection.
• Check with your doctor before you receive any vaccine while you are using Advair Diskus.
• Diabetes patients - Advair Diskus may affect your blood sugar. Check blood sugar levels closely. Ask your doctor before you change the dose of your diabetes medicine.
• Lab tests, including lung function tests and eye exams, may be performed while you use Advair Diskus. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
• Use Advair Diskus with caution in the elderly.
• Corticosteroids may affect growth rate in children and teenagers in some cases. They may need regular growth checks while they use Advair Diskus.
• Advair Diskus should not be used in children younger than 4 years old; safety and effectiveness in these children have not been confirmed.
• Pregnancy and breast-feeding: If you think you may be pregnant, contact your doctor. You will need to discuss the benefits and risks of using Advair Diskus while you are pregnant. It is not known if Advair Diskus is found in breast milk. If you are or will be breast-feeding while you use Advair Diskus, check with your doctor. Discuss any possible risks to your baby.

All medicines may cause side effects, but many people have no, or minor, side effects.

Check with your doctor if any of these most common side effects persist or become bothersome:

Diarrhea; dizziness; headache; mild muscle or bone pain; nausea; nervousness; throat irritation; tremor; vomiting.

Seek medical attention right away if any of these severe side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); behavior changes; blurred vision or other vision changes; chest pain; choking; fast or irregular heartbeat; hoarseness; numbness or tingling in hands or feet; seizures; severe muscle weakness, cramps, or spasms; severe or persistent bone pain; severe or persistent dizziness or headache; signs of infection (eg, fever, chills, persistent headache/sore throat, ear pain, increased mucus production or change in mucus color); swelling or tightness in the throat; trouble sleeping; unusual tiredness or weakness; vaginal odor or discharge; weight gain; white patches or sores on the tongue or mouth; worsening of asthma symptoms (eg, increased wheezing, coughing, chest tightness, shortness of breath).

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider.