You should not use this medication if you are allergic to probenecid, or if you have uric acid kidney stones, a gout attack that has already started, or a blood cell disorder such as anemia, or decreased white blood cells. Probenecid should not be given to a child younger than 2 years old.

Before taking probenecid, tell your doctor if you are allergic to any drugs, or if you have kidney disease, a history of stomach ulcer, or if you have ever had kidney stones.
Drink plenty of water to prevent kidney stones while you are taking probenecid.

Benemid may be only part of a complete program of treatment that also includes diet, other medications, and mineral supplements. Follow your doctor's instructions.
Call your doctor at once if you have worsening gout symptoms, severe pain in your side or lower back, blood in your urine, swelling, fever, pale or yellowed skin, or dark-colored urine.

You should NOT use this medication if you are allergic to probenecid, or if you have:

• uric acid kidney stones;
• a gout attack that has already started; or
• a blood cell disorder such as anemia, or decreased white blood cells. 

Before taking Benemid, tell your doctor if you are allergic to any drugs, or if you have:

• kidney disease;
• a history of stomach ulcer; or
• if you have ever had kidney stones. 

If you have any of these conditions, you may need a dose adjustment or special tests to safely take Benemid.
Benemid may be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment. It is not known whether probenecid passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby. Probenecid should not be given to a child younger than 2 years old.

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have a serious side effect such as:

• worsening gout symptoms;
• severe pain in your side or lower back;
• blood in your urine;
• swelling, especially in your face, stomach, ankles, or feet; or
• pale or yellowed skin, dark colored urine, fever, confusion or weakness.

Less serious side effects may include:

• urinating more than usual;
• mild nausea, vomiting, loss of appetite;
• headache, dizziness;
• sore gums;
• mild itching or skin rash;
• hair loss; or
• warmth, redness, or tingly feeling under your skin.

This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect.